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Abstract Background Oligodendrocytes are glial cells that support and insulate axons in the central nervous system through the production of myelin. Oligodendrocytes arise throughout embryonic and early postnatal development from oligodendrocyte precursor cells (OPCs). and recent work demonstrated that they are a transcriptional heterogeneous cell population. but the regional and func...

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Degeneration of the retinal pigment epithelium (RPE) plays a central role in age-related macular degeneration (AMD). Throughout life. RPE cells are challenged by a variety of cytotoxic stressors. some of which are cumulative with age and may ultimately contribute to drusen and lipofuscin accumulation.

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