Background: In sickle cell disease (SCD). reduced bioavailability of endothelial NO and cGMP results in reduced expression of phosphodiesterase type 5 (PDE5). thus impairing the penile erection control mechanism and resulting in prolonged penile erection (priapism). In SCD. https://www.roneverhart.com/Aftermath-Cabernet-Sauvignon-Napa-Valley-2017/