DENV belongs to the Flaviviridae family and possesses a single-stranded RNA genome of positive polarity. DENV infection manifests in mild subclinical forms or severe forms that may be dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Despite a lot of effort worldwide. the exact mechanism underlying the pathogenesis of severe DENV infection remains elusive. https://www.roneverhart.com/Hugger-Backpack-20L/