Abstract We describe a robust. fiducial-free method of drift correction for use in single molecule localization-based super-resolution methods. The method combines periodic 3D registration of the sample using brightfield images with a fast post-processing algorithm that corrects residual registration errors and drift between registration events. The method is robust to low numbers of ... https://poolsproductscanadas.shop/product-category/sta-rite-system-3-parts/